The purpose of this study is a quantitative evaluation on technology know-how based on research and development by the Japanese manufacturing industry. Via a questionnaire survey, the economic magnitude and variation of the technology know-how in each industrial field is studied. Based on this study, we estimate quantitatively the unintended technology know-how leakage. Furthermore, the effective management to protect technology know-how leakage is shown by clarifying the effect of the level of trade secret protection and detailed management methods conducted by industry on the technology know-how leakage.